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Vasoactive Intestinal Peptide (Plasma/GI Tube)
Test Code13986
Alias/See Also
LAB1107
CPT Codes
84586<br><strong>This test is not available for New York patient testing.</strong>
Preferred Specimen
1 mL plasma collected in an EDTA (lavender-top) tube
Patient Preparation
Patient should be fasting 10-12 hours prior to collection of specimen.
Patient should not be on any antacid medication or medications that affect intestinal motility for at least 48 hours prior to collection.
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plasma collected in a G.I. preservative tube
Special G.I. preservative tubes are available from Inter Science (ISI).
Special G.I. preservative tubes are available from Inter Science (ISI).
Instructions
Centrifuge, separate and freeze plasma as soon as possible
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 6 months
Refrigerated: 7 days
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Grossly icteric
Methodology
Direct Enzyme Immunoassay/Enzyme Linked Immunosorbent Assay
FDA Status
This test was developed and its performance characteristics have been determined by Inter Science Institute. Values obtained with different methods, laboratories, or kits cannot be used interchangeably with the results on this report. The results cannot be interpreted as absolute evidence of the presence or absence of malignant disease.
This test is not available for New York patient testing.
Setup Schedule
Mon-Fri
Report Available
4-7 days
Reference Range
<36 pg/mL
Clinical Significance
Vasoactive intestinal polypeptide (VIP) is a 28 amino acid multifunctional peptide that is involved in gastrointestinal, vasodilator, and neuroendocrine functions. VIP is derived from larger pro-molecules that often exhibit the same or greater immunogenicity than the native VIP. It is structurally related to phim, glucagon, secretin, gastric inhibitory polypeptide, corticotropin releasing factor and growth hormone-releasing hormone. VIP stimulates pituitary release of prolactin, growth hormone and ACTH; Stimulates luteinizing hormone-releasing hormone, serotonin, gastric somatostatin, steroids and renin. VIP inhibits the release of gastrin, hypothalamic somatostatin, and histamine. VIP release is stimulated by cholinergic agonists, atropine, serotonin, prostaglandins e1 and d2, and nerve growth factor. VIP actions are inhibited by corticosteroids, dopamine and opiate agonists. Elevated levels of VIP are found in patients with vipomas, hepatic cirrhosis, and the verner-morrison's (watery diarrhea) syndrome. Decreased levels are found in cystic fibrosis.
Performing Laboratory
Interscience Institute |
944 W Hyde Park Blvd |
Inglewood, CA 90302-3308 |