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AVISE Vasculitis AAV
MessageSpecimens can be collected Monday-Thursday and before 1400EST on Fridays. Do NOT collect specimens on weekends or holidays.
A manual requisition will be sent from the Rheumatology office that needs to be sent with the specimens.
AVISE tests require special collection tubes kept in outpatient and processing.
A manual requisition will be sent from the Rheumatology office that needs to be sent with the specimens.
AVISE tests require special collection tubes kept in outpatient and processing.
Test Code
LAB01220
Alias/See Also
Exagen AVISE Vasculitis-AAV
LAB01220
LAB01220
Includes
Anti-PR3, Anti-GBM, Anti-MPO, ANCA
Preferred Specimen
AVISE Collect kit:
1 - Marble
1 - Marble
Transport Container
AVISE Shipping Kit
Transport Temperature
Refrigerated - Ice pack required when preparing AVISE Shipping kit.
Specimen Stability
Stability of 48 hours when Marble tube has been spun down.
Report Available
4-7 days
Clinical Significance
Anti-PR3 antibodies are primarily associated with GPA and to a lesser extent, found in MPA (10%) and EGPA. However, anti-PR3 antibodies can also be seen in connective tissue disease, IBD, some infections, malignancy, and as a reaction to drugs. Therefore, results should be interpreted with care in light of the clinical findings and workup.
Anti-GBM antibodies are often associated with Goodpasture's disease and anti-GBM nephritis. A significant proportion of patients with anti-GBM disease are also positive for ANCA.
Anti-MPO antibodies are primarily associated with MPA and to a lesser extent, found in GPA (6%) and EGPA. However, anti-MPO antibodies can also be seen in connective tissue disease, IBD, some infections, malignancy, and as a reaction to drugs. Therefore, results should be interpreted with care in light of the clinical findings and workup.
The c-ANCA pattern produces a granular cytoplasmic pattern with interlobular accentuation on ethanol fixed neutrophils. c-ANCA patterns are associated with necrotizing segmental glomerulonephritis and GPA.
The p-ANCA pattern produces perinuclear staining with or without nuclear extension. The p-ANCA patter is commonly detected in patients with MPA and about 40% of patients with EGPA.
Anti-GBM antibodies are often associated with Goodpasture's disease and anti-GBM nephritis. A significant proportion of patients with anti-GBM disease are also positive for ANCA.
Anti-MPO antibodies are primarily associated with MPA and to a lesser extent, found in GPA (6%) and EGPA. However, anti-MPO antibodies can also be seen in connective tissue disease, IBD, some infections, malignancy, and as a reaction to drugs. Therefore, results should be interpreted with care in light of the clinical findings and workup.
The c-ANCA pattern produces a granular cytoplasmic pattern with interlobular accentuation on ethanol fixed neutrophils. c-ANCA patterns are associated with necrotizing segmental glomerulonephritis and GPA.
The p-ANCA pattern produces perinuclear staining with or without nuclear extension. The p-ANCA patter is commonly detected in patients with MPA and about 40% of patients with EGPA.
Performing Laboratory
Exagen Inc.