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Cyclosporine A Peak (2 Hour), Blood
Test Code10719
Alias/See Also
LAB00170
CPT Codes
80158
Preferred Specimen
2 mL whole blood collected in an EDTA (lavender-top) tube
Patient Preparation
Collect as a peak, 2 hours post-dose
Minimum Volume
1 mL
Transport Container
EDTA (lavender-top) tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted specimen
Methodology
Immunoassay (IA)
Setup Schedule
Daily
Report Available
3-4 days
Reference Range
No definitive therapeutic or toxic ranges have been established. Optimal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation. The following peak ranges are suggested guidelines:
de novo | 1500-1700 mcg/L | |||||
<6 Months | 800-1000 mcg/L | |||||
6-12 Months | 600-800 mcg/L | |||||
>1 Year | 300-600 mcg/L |
Clinical Significance
Cyclosporine (Cyclosporin A) is an immunosuppressant therapeutic agent used in the prevention of organ graft rejection. Clinical measurement of blood levels is required due to the inter-individual variability of metabolism as well as the toxicity associated with excessive dosage.
Performing Laboratory
Quest Diagnostics Nichols Institute-Chantilly VA |
14225 Newbrook Drive |
Chantilly, VA 20151-2228 |