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Quest AD-Detect® Phosphorylated tau181(p-tau181), Plasma
Test Code13690
Alias/See Also
LAB01222
CPT Codes
84393
Preferred Specimen
1 mL plasma collected in EDTA (lavender-top) tube
Patient Preparation
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Minimum Volume
0.5 mL
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 22 days
Frozen: 22 days
Refrigerated: 22 days
Frozen: 22 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
Electrochemiluminescence (ECLIA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Mon-sat
Report Available
2-5 days
Reference Range
<55 years | ≤0.86 pg/mL |
≥55 years | ≤1.07 pg/mL |
Clinical Significance
p-tau181 is a diagnostic biomarker for Alzheimer's Disease (AD) that is useful in identifying patients with underlying AD tau pathology. It can predict the cognitive decline in AD/MCI patients and correlates with amyloid and tau PET results.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |