A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Estradiol
Test Code4021
Alias/See Also
LAB523
CPT Codes
82670
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
Note: For any patients for whom low estradiol levels are anticipated (e.g. males, pre-pubertal children and hypogonadal/post-menopausal females), the Quest Diagnostics Estradiol, Ultrasensitive, LC/MS/MS assay is recommended (test code 30289).
Note: Do not add on estradiol testing to a barrier gel specimen older than 72 hours. Estradiol binds to barrier gel causing decreased values.
Note: Do not add on estradiol testing to a barrier gel specimen older than 72 hours. Estradiol binds to barrier gel causing decreased values.
Transport Container
Serum separator tube (SST)
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 6 months
*Do not add estradiol testing to a barrier gel specimen older than 72 hours
Refrigerated: 7 days
Frozen: 6 months
*Do not add estradiol testing to a barrier gel specimen older than 72 hours
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum stored on barrier gel for more than 72 hours
Methodology
Immunoassay (IA)
Setup Schedule
Mon-Sat
Report Available
2-3 days
Reference Range
Female | ||||||
Follicular Phase | 19-144 pg/mL | |||||
Mid-Cycle | 64-357 pg/mL | |||||
Luteal Phase | 56-214 pg/mL | |||||
Postmenopausal | ≤31 pg/mL | |||||
Male | ≤39 pg/mL |
Clinical Significance
Measuring the circulating levels of estradiol is important for assessing the ovarian function and monitoring follicular development for assisted reproduction protocols. Estradiol plays an essential role throughout the human menstrual cycle. Elevated estradiol levels in females may also result from primary or secondary ovarian hyperfunction. Very high estradiol levels are found during the induction of ovulation for assisted reproduction therapy or in pregnancy. Decreased estradiol levels in females may result from either lack of ovarian synthesis (primary ovarian hypofunction and menopause) or a lesion in the hypothalamus-pituitary axis (secondary ovarian hypofunction). Elevated estradiol levels in males may be due to increased aromatization of androgens, resulting in gynecomastia.
Performing Laboratory
Quest Diagnostics Nichols Institute-Chantilly VA |
14225 Newbrook Drive |
Chantilly, VA 20151-2228 |