KEPPRA-LEVETIRACETAM LEVEL

Test Code
KEPQ

CPT Codes
80177

Preferred Specimen
1 mL serum collected in a (red-top tube (no gel))

Minimum Volume
0.5

Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, EDTA (royal blue-top) tube or sodium heparin (green-top) tube

Instructions
Collect in red-top tube (no gel). Avoid use of Serum Separator Tubes (SST®s) as the drug may be adsorbed to the gel.

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 14 days
Refrigerated: 28 days
Frozen: 60 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum Separator Tube (SST)

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Reference Range
Drug Dosage/Trough/Peak
  mg BID   mcg/mL    mcg/mL
     500:     3.1-10.0   10.0-25.0
   1000:     4.9-37.1   30.0-40.0
   1500:     7.0-34.0   36.1-70.0

Clinical Significance
Levetiracetam is an anticonvulsant used as adjunct therapy to treat adult partial seizures. As multiple anticonvulsants are administered, it is important to monitor its level to (1) optimize therapy, (2) assure compliance, and (3) to avoid toxicity.



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.