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KEPPRA-LEVETIRACETAM LEVEL
Test CodeKEPQ
CPT Codes
80177
Preferred Specimen
1 mL serum collected in a (red-top tube (no gel))
Minimum Volume
0.5
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, EDTA (royal blue-top) tube or sodium heparin (green-top) tube
Instructions
Collect in red-top tube (no gel). Avoid use of Serum Separator Tubes (SST®s) as the drug may be adsorbed to the gel.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 28 days
Frozen: 60 days
Refrigerated: 28 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum Separator Tube (SST)
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Reference Range
Drug Dosage/Trough/Peak
mg BID mcg/mL mcg/mL
500: 3.1-10.0 10.0-25.0
1000: 4.9-37.1 30.0-40.0
1500: 7.0-34.0 36.1-70.0
mg BID mcg/mL mcg/mL
500: 3.1-10.0 10.0-25.0
1000: 4.9-37.1 30.0-40.0
1500: 7.0-34.0 36.1-70.0
Clinical Significance
Levetiracetam is an anticonvulsant used as adjunct therapy to treat adult partial seizures. As multiple anticonvulsants are administered, it is important to monitor its level to (1) optimize therapy, (2) assure compliance, and (3) to avoid toxicity.