14-3-3 eta Protein

Test Code
91455

CPT Codes
83520

Preferred Specimen
1 mL serum

Minimum Volume
0.5 mL

Instructions
Allow blood to clot (10-15 minutes) at room temperature. Centrifuge and separate from cells. Freeze as soon as possible. Ship refrigerated.

Transport Container
Plastic screw-cap vial

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 21 days

Methodology
Enzyme Linked Immunosorbent Assay (ELISA)

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range
<0.2 ng/mL

Clinical Significance
The 14-3-3η protein appears to contribute to the pathologic process of joint erosion and, as such, is an emerging biomarker of joint damage in rheumatoid arthritis (RA) and psoriatic arthritis. Concentrations are significantly higher in people with active joint disease than in those with inactive RA or psoriasis without arthritis. Measurement of 14-3-3η complements RF and CCP antibody tests and may improve diagnostic sensitivity.



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.