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Vancomycin Trough

Test Code
VANT


Alias/See Also
Vancocine


CPT Codes
80202

Preferred Specimen

Serum (gold or red top tube)



Minimum Volume
0.5 mL


Other Acceptable Specimens
Serum or EDTA Plasma


Instructions

Collect a trough sample just before the next scheduled dose. When adjusting dosage, measure peak and trough levels during the same dosing intervals.

Specimen should be protected from prolonged exposure to light.



Transport Container

Serum (gold or red top) or EDTA Plasma (purple top) Tube



Transport Temperature
Room Temperature or Refrigeration


Specimen Stability
Room Temperature - 2 hours; Refrigerated - 3 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Quantity Not Sufficient, IV Contamination


Methodology
Photometric

Setup Schedule

Daily upon receipt



Report Available
Upon completion of analysis


Limitations
Patients with decreased renal function may generate vancomycin crystalline degradation product (CDP-1). CDP-1 is metabolically inactive and is not measured in this assay.


Reference Range

Therapeutic Trough Range:  15 - 20 ug/mL



Clinical Significance

Vancomycin is used in the treatment of serious or severe infections caused by gram-positive organisms resistant to penicillins, cephalosporins, or other antimicrobial agents. It is also used in the treatment of antibiotic-associated pseudomembranous colitis produced by Clostridium difficile.  The risk of ototoxicity and nephrotoxicity is increased in patients with impaired renal function, and in patients receiving concurrent aminoglycoside treatment.  Serum or plasma vancomycin measurements are used in the diagnosis and treatment of vancomycin overdose and in monitoring levels of vancomycin to ensure appropriate therapy.





The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.