Urine Osmolality

Random or Timed Urine Specimen

Collect random or timed specimen per orders.  For timed specimen, record start and stop time of collection or number of hours.  To transfer specimen from large container to smaller container for transport, measure volume first and record on smaller container, along with start/stop time or hours of collection.  Timed specimens are typically collected for 24 hours, but can be collected in other increments, for example, 4 hours or 12 hours.

This test is for Osmolality measurement on Urine.  For Osmolality measurement on Plasma or Serum, order OSMO.  For Osmolality measurement on Body Fluids, order MISOSMO.

24-hour urine container or sterile urine cup

Monday - Sunday, 8:00 am - 3:00 pm upon receipt

Urine Volume:  800- 1800 mL/24 hours
Osmolality:       300 - 1090 mOsm/kg

 Urine Osmolality is useful for assessing the concentrating and diluting ability of the kidney.

Osmolality is an index of the solute concentration. Urine osmolality is a measure of the concentration of osmotically active particles, principally sodium, chloride, potassium, and urea; glucose can contribute significantly to the osmolality when present in substantial amounts in urine. Urinary osmolality corresponds to urine specific gravity in nondisease states.

The ability of the kidney to maintain both tonicity and water balance of the extracellular fluid can be evaluated by measuring the osmolality of the urine either routinely or under artificial conditions. More information concerning the state of renal water handling or abnormalities of urine dilution or concentration can be obtained if urinary osmolality is compared to serum osmolality and if urine electrolyte studies are performed. Normally, the ratio of urine osmolality to serum osmolality is 1.0 to 3.0, reflecting a wide range of urine osmolality.

With normal fluid intake and normal diet, a patient will produce a urine of about 500 to 850 mosmol/kg water. Above age of 20 years there is an age dependent decline in the upper reference range of approximately 5 mOsm/kg/year.

The normal kidney can concentrate a urine to 800 to 1,400 mOsm/kg and with excess fluid intake, a minimal osmolality of 40 to 80 mOsm/kg can be obtained.

With dehydration, the urine osmolality should be 3 to 4 times the plasma osmolality.

This test is for Osmolality measurement on Urine.  For Osmolality measurement on Plasma or Serum, order OSMO.  For Osmolality measurement on Body Fluids, order MISOSMO.