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TRH Stimulation Profile
MessageRefer to TRH(TSH) Stimulation test located on WTH Intranet for test instructions or instructions below.
Test Code
CPT Codes
80438
Includes
Preferred Specimen
Serum (gold top tube) - 1.0 mL
Minimum Volume
Other Acceptable Specimens
Instructions
TRH: MUST BE SCHEDULED IN NURSING. Draw one red top tube for specific times and label a This procedure is performed by nursing as it involves use of a port and adminstration of Thyrotropin(ordered by physician from pharmacy). Draw one red top tube for specific times and label accordingly. NOTIFY LAB IMMEDIATELY AFTER THYROTROPIN IS ADMINISTERED. Blood for TSH's should be drawn from heplock at 20 minutes, 30 minutes and 60 minutes following injection of Thypinone.
Transport Container
Serum (gold top) or Lithium Heparin Plasma (green top) tube
Transport Temperature
Specimen Stability
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Chemiluminescence
Setup Schedule
MUST BE SCHEDULED WITH NURSING.
Report Available
Limitations
Reference Range
0.465 - 4.68 mIU/mL
Clinical Significance
TSH secretion by the anterior pituitary is controlled by thyrotropin releasing hormone, a tripeptide produced by the hypothalmus. TSH simulates the production of thyroxine(T4) and triidothyronine(T3) by the thyroid gland. The circulating free fractions of T4 and T3 in turn regulate the secretion of TSH by a negative feedback mechanism at the pituitary and the hypothalmus. The diagnosis of overt hypothyroidism by the finding of a low T4 or FT4 concentration is readily confirmedby a raised TSH concentration. Measurement of low or undetectable TSH concentrations may assist the diagnosis of hyperthyroidism where concentrations of T4 and T3 are elevated and TSH secretion is suppressed.