Immunochemical MB

Test Code

IMBS

Alias/See Also

CK-MB, Creatine Kinase-MB, Creatine Phosphokinase-MB, CK-MB Isoenzyme

CPT Codes
82553

Preferred Specimen

Serum (gold top) tube

Minimum Volume

0.5 mL

Other Acceptable Specimens

Lithium Heparin Plasma (green top) tube

Instructions

This test is for the measurement of the CK isoenzyme CK-MB on Plasma or Serum. For a measurement of total CK on Plasma or Serum, order CPK. For measurement of CK on Body Fluids, order MISCK.

Transport Container

Serum (gold top) tube or Lithium Heparin Plasma (green top) tube

Transport Temperature

Room Temperature or Refrigeration

Specimen Stability

Room Temperature - 3 hours; Refrigerated - 5 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Turbidity, Quantity Not Sufficient, IV contamination

Methodology
Chemiluminescence

Setup Schedule

Daily upon receipt

Report Available

Upon completion of analysis

Reference Range

0.0 - 3.4 ng/mL

Clinical Significance

Creatine kinase (CK) is a key enzyme of energy metabolism in muscle, catalyzing the reversible phosphorylation of creatine. This dimeric enzyme has two active subunits, M and B, which associate to form three isoenzymes, CK-MM, CK-MB and CK-BB. CK-MM is found predominantly in skeletal muscle and CK-BB in brain. CK-MB is found predominantly in cardiac muscle accounting for approximately 10–40% of myocardial CK. The low concentration of CK-MB in normal serum and non-cardiac tissues is the basis of its widely accepted use as a diagnostic indicator of myocardial injury. Damage to the myocardium results in a transient release of CK-MB into the circulation. This increase in CK-MB reaches a peak in 12 to 24 hours, then returns to normal within 48 to 72 hours. This characteristic temporal pattern is diagnostic for AMI. Approximately 98% of patients with AMI exhibit elevated serum CK-MB while only 3% of non-AMI patients exhibit abnormal CK-MB.

This test is for the measurement of the CK isoenzyme CK-MB on Plasma or Serum. For a measurement of total CK on Plasma or Serum, order CPK. For measurement of CK on Body Fluids, order MISCK.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.