IgM Antibodies

Test Code

IGM

CPT Codes
82784

Preferred Specimen

0.5 Red

Minimum Volume

0.5 mL

Transport Container

Serum (gold or red top) Tube

Transport Temperature

Room Temperature or Refrigeration

Specimen Stability

Room Temperature - 1 day; Refrigerated - 7 days

Methodology
Photometric

Setup Schedule

Daily upon receipt

Report Available

Upon completion of analysis

Reference Range

40 - 230 mg/dL

Clinical Significance

IgM is the first immunoglobulin synthesized in response to antigenic challenge and accounts for 5 to 10% of the total circulating immunoglobulins. The role of IgM in activating the complement cascade and promoting phagocytosis makes it an important factor in eliminating particulate antigens and microorganisms from the circulation. IgM levels are used to evaluate monoclonal proteins seen on serum electrophoresis, and to monitor the progression or therapeutic response of patients with macroglobulinemia. Levels are frequently increased in viral infections, rheumatoid arthritis, and chronic hepatocellular disease, active sarcoidosis, Waldenström’s macroglobulinemia, and malignant lymphoma. Decreased levels are seen in association with recurrent, chronic, or severe infections, multiple myeloma (IgA or IgG), and protein-losing enteropathy (but not nephrotic syndrome).

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.