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Hypercoag/Thrombosis Pan
MessageConsists of a Functional Protein C, Protein S Activity, Anti-thrombin III, Fibrinogen, APTT, PT, Activated Protein C Resistance, Lupus Anticoagulant Panel, Pt Nucleotide 20210A, and Homocysteine. An elevated Homocysteine reflexes Methylenetetrahydrofolate Reductase Mutation (Sent to Quest) and a borderline or positive APCR reflexes DNA testing for FVL.
Test Code
Includes
Preferred Specimen
4 Blue, 2 Lav, 3 Red
Instructions
Refer to instructions for individual tests included in profile for proper processing and transport instructions.
Specimen Stability
Methodology
Refer to Individual Testing
Setup Schedule
Performed M, W & F
Report Available
Reference Range
Refer to Individual Testing
Clinical Significance
Disorders of thrombosis may occur as a result of breakdowns or abnormalities in one or more mechanisms of hemostasis. Patients with these disorders are at increased risk of thrombus formation and may be termed "hypercoagulable." Thrombotic disorders have many different etiologies but are typically classified as primary or secondary. Primary disorders are usually inherited and refer to specific quantitative or qualitative deficiencies in components of hemostasis. Conversely, secondary disorders are more common, often acquired and may be associated with clinical conditions which contribute to increased incidence of thromboembolism. Platelet, vessel wall and blood flow abnormalities may also predispose patients to thrombotic episodes. In selecting laboratory tests for diagnosing hypercoagulability one must consider whether the patient's history suggests ongoing thrombosis or rather a specific deficiency that increases the patient's risk of thrombosis. Laboratory tests detecting ongoing thrombosis include those that measure platelet activation, activation of the clotting sequence, thrombotic inhibitors, or thrombin generation.