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H.Pylori (Stool) Antigen
Test CodeHPSA
Alias/See Also
Helicobactor pylori antigens
CPT Codes
87338
Preferred Specimen
Stool
Minimum Volume
0.5 ml stool
Other Acceptable Specimens
none
Instructions
Transport specimen in an air tight container at 2-8 C for up to 72 hours. After 72 hours, specimen must be frozen at -20C or below.
Transport Container
STOOL/0.5
Transport Temperature
2-8 C or frozen at -20
Specimen Stability
At -20C indefinitely
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Storage in transport media, on swabs, or mixed with preservative is not acceptable for testing.
Methodology
MAN
Setup Schedule
daily
Report Available
24
Limitations
Antimicrobials, proton pump inhibitors and bismuth preparations are known to suppress H. pylori and ingestion of these days prior to testing could cause false negative results.
Reference Range
Negative
Clinical Significance
The detection of Helibactor pylori is a causative agent of chronic gastritis and peptic ulcer disease, and has been associated with mucosa-associated lymphoid tissue lymphoma and gastric adenocarcinoma. Patients who harber the organisms are divided into 2 basic groups. (1)Patients are asymptomatic and are considered "colonized". (2) The second group shows gastrointestinal symptoms and is considered as "infected". Possible routes of transmission of H. pylori to humans are through animals, contaminated water and oral reservoirs.