A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Hexagonal Phospholipid Neut.
Test CodeCPT Codes
85598
Preferred Specimen
1 blue
Minimum Volume
Other Acceptable Specimens
Instructions
This is a reflex test in the Lupus Anticoagulant panel. Outreach clients should double-spin the blue top plasma, remove the plasma from the RBC button, and freeze in a polypropylene tube.
Transport Container
Blue, polypropylene tube
Transport Temperature
Specimen Stability
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Clotting Time Measurement
Setup Schedule
Monday & Thursday 0600-1300
Report Available
Reference Range
the reference time is the delta T cut-off time in seconds. the delta T set for this laboratory is 9 seconds.
< 9 seconds = Negative
> or = 9 seconds = Positive
Qualitative Result Only Reported
Clinical Significance
Lupus anticoagulants (LA) are immunoglobulins that generally interfere with phospholipid-dependent in vitro coagulation tests, the most frequently used being the activated partial thromboplastin time (APTT) assay. The common association of LA with recurrent spontaneous abortions and idiopathic thromboembolic diseases underlies the importance of diagnostic tests capable of distinguishing these LA antibodies from anti-factor antibodies, factor deficiencies and heparin, since all four conditions may cause a prolongation of the APTT test. The diagnosis of LA is often difficult because of variable reagent sensitivity and the intrinsic heterogeneity of LA. In practice, factor deficient plasmas are easily identified, since the addition of normal plasma restores normal in vitro clotting time. However, the APTT test alone cannot provide clear-cut differentiation between LA antibody-containing plasmas and those that contain anti-factor antibodies and/or heparin.