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Haptoglobin
Test CodeHAPT
CPT Codes
83010
Preferred Specimen
Serum (gold or red top tube)
Minimum Volume
0.5 mL
Transport Container
Serum (gold or red top) Tube
Transport Temperature
Room Temperature or Refrigeration
Specimen Stability
Room Temperature - 3 months; Refrigerated - 3 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis, Turbidity, Quantity Not Sufficient, EDTA (purple top tube) contamination, IV contamination
Methodology
Turbidimetric
Setup Schedule
Daily upon receipts
Report Available
Upon completion of analysis
Reference Range
30 - 200 mg/dL
Clinical Significance
Haptoglobin is an acute phase reactant. This term refers to proteins whose serum concentrations rise significantly during acute inflammation due to causes including surgery, myocardial infarction, infections and tumors. Haptoglobin binds free hemoglobin in plasma. The hemoglobin/haptoglobin complexes are removed from circulation by the reticulo-endothelial system. Decreased haptoglobin concentrations are generally indiciative of erythrocyte destruction. Levels of haptoglobin may appear increased in conditions of burns and nephrotic syndrome when large amounts of fluid and lower-molecular weight plasma proteins have been lost.