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Gentamicin Peak
Test CodeAlias/See Also
CPT Codes
80170
Preferred Specimen
Serum (gold top) tube
Minimum Volume
Other Acceptable Specimens
Instructions
To obtain a concentration that best represents the peak tissue level, draw the sample one hour after an intramuscular injection, 30 minutes after ending a 30- minute intravenous infusion, or immediately after a 60-minute intravenous infusion. Collect a trough sample just before the next scheduled dose. When adjusting dosage, measure peak and trough levels during the same dosing intervals.
Transport Container
Serum (gold top) tube, Lithium Heparin Plasma (green top) tube or EDTA Plasma (purple top) Tube
Transport Temperature
Specimen Stability
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Photometric
Setup Schedule
Daily upon receipt
Report Available
Limitations
Reference Range
No reference range listed for Gentamycin Peak. Critical high starts at 23.9 ug/mL.
Clinical Significance
Gentamicin is used in the treatment of serious infections caused by susceptible strains of gram-negative microorganisms and particular gram-positive organisms that are resistant to less toxic antibiotics. Gentamicin is safe and effective only in a narrow range of concentrations for a given indication. Exposure to high gentamicin concentrations for a prolonged period may cause renal impairment or ototoxicity. Serum or plasma gentamicin measurements are used in the diagnosis and treatment of gentamicin overdose and in monitoring levels of gentamicin to ensure appropriate therapy.