A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Estradiol
Test CodeCPT Codes
82670
Preferred Specimen
Green
Minimum Volume
Other Acceptable Specimens
Transport Container
Serum (gold top) tube or Lithium Heparin Plasma (green top) tube
Transport Temperature
Specimen Stability
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Chemiluminescence
Setup Schedule
Daily upon receipt
Report Available
Reference Range
Male: 5 - 66 pg/mL
Female:
Follicular Phase: 27 - 161 pg/mL
Pre-Ovulatory Peak: 187 - 132 pg/mL
Luteal Phase 33 - 201 pg/mL
Post-Menopausal Phase: 5 - 38 pg/mL
Clinical Significance
Estradiol is produced by the adrenals, placenta, and testes and is the principal estrogen secreted by the ovaries. Over 98% of circulating estradiol is bound to serum proteins, principally sex hormone binding globulin (SHBG). Metabolic clearance of estradiol is effected by conversion to estrone, and by hydroxylation and conjugation with sulfate or glucuronide. Estradiol normally exerts negative feedback control on gonadotropin release, however, as estradiol production accelerates with the rapid growth of the dominant follicle, this feedback becomes positive, causing a surge in LH secretion, and ovulation occurs. The measurement of estradiol is useful in assessing a variety of menstrual dysfunctions including delayed puberty, amenorrhoea and menopause.