Dil Russell Vip.Venon Confirm

Test Code

DRVVTC

Alias/See Also

DRVV Confirm

Preferred Specimen

1 Blue

Minimum Volume

Blue tops must be filled to Minimum Fill Indicator Line on tube.

Other Acceptable Specimens

none

Instructions

Included in Lupus Anticoagulant Profile. Oral anticoagulants will prolong test. Abnormal DRVV Screen reflexes DRVV Confirm. Outreach clients should double-spin the blue top plasma, remove the plasma from the RBC button, and freeze in a polypropylene tube.

Both the DRVV screen and the DRVV confirm should be performed at the same time and on the same sample.

Transport Container

Blue; Polypropylene tube

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Sample must be free of clots and hemolysis.

Methodology
Clotting Activation

Setup Schedule

Monday and Thursday 0630-1500

Report Available

Upon Completion of Analysis

Limitations

Samples from patients receiving Heparin should not be used

Reference Range

DRVV Scr Ct: 25 - 47 sec

DRVV Scr Ratio: <1.2

DRVV Confirm Ct: 27 - 39 sec

DRVV Confirm Ratio: <1.2

Normalized Ratio: <1.2

Clinical Significance

Lupus anticoagulants are antibodies directed against phospholipid/protein complexes. They have the ability to prolong the clotting times of the phospholipid-dependent tests. Lupus anticoagulants are associated with numerous clinical states such as: auto-immune diseases (systemic lupus erythematosus), thromboses, recurrent spontaneous abortions and infections. Their presence may be persistent or transitory. The Russell’s viper venom is present in the dRVV Screen and dRVV Confirm reagents. This venom acts in the presence of calcium as an activator of factor X and thereby triggers the coagulation cascade downstream from factor X, thus eliminating the influence of coagulation factors acting upstream. This test is not affected by the contact factor anomalies or by factor VIII and IX deficiencies or inhibitors. The dRVV Screen test is performed with a low concentration of phospholipids. If LA are present, the clotting time will be lengthened. The dRVV Confirm test is performed with a higher concentration of phospholipids which neutralize the LA present in the plasma being tested. Therefore the clotting time obtained with the dRVV Confirm will be shorter than the one observed with the dRVV Screen.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.