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Dic Follow-Up Profile
Test CodeIncludes
Preferred Specimen
2 Blue, 1 Lav
Other Acceptable Specimens
Instructions
Refer to instructions for individual tests included in profile for proper processing and transport instructions.
Transport Container
Blue, Lav, polypropylene tube
Specimen Stability
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Refer to Individual Testing
Setup Schedule
Daily upon Receipt
Report Available
Reference Range
Refer to Individual Testing for Reference Ranges
Clinical Significance
DIC (Disseminated Intravascular Coagulation) is an uncontrolled activation of the clotting system in response to an underlying process, with consumption of platelets and coagulation factors and generation of fibrin degradation products. Patients with severe DIC can develop systemic bleeding. Underlying causes of DIC include severe infection (usually gram negative), complications of pregnancy (amniotic fluid embolism, premature separation of the placenta, septic abortion, and retained dead fetus), malignancy, massive tissue trauma, hemorrhagic shock, severe liver disease, burns, and severe hemolysis. Typical laboratory findings in DIC include increased PT, PTT, and FDP's; decreased fibrinogen levels, platelet count, ATIII levels; a positive D-Dimer, and schistocytes and microspherocytes on the peripheral smear.