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Ddimer(VTE) ER/OP Only
Test CodeCPT Codes
85379
Preferred Specimen
1 Sodium Citrate Blue
Minimum Volume
Other Acceptable Specimens
Instructions
Outreach clients should double-spin the blue top plasma, remove the plasma from the RBC button, and freeze in a polypropylene tube.
Transport Container
BLUE/1
Transport Temperature
Specimen Stability
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Immuno-Turbidimetric
Setup Schedule
Daily on Receipt
Report Available
Reference Range
Ddimer (VTE) NPV (Negative Predictive Value) is less than 0.45 ug/mL FEU
Clinical Significance
The specific degradation of fibrin (i.e., fibrinolysis) is the reactive mechanism responding to the formation of fibrin. Plasmin is the fibrinolytic enzyme derived from inactive plasminogen. Plasminogen is converted into plasmin by plasminogen activators. The main plasminogen activators are tissue plasminogen activator (tPA) and pro-urokinase which is activated into urokinase (UK) by, among others, the contact system of coagulation. In the bloodstream, plasmin is rapidly and specifically neutralized by alpha 2-antiplasmin, thereby restricting its fibrinogenolytic activity and localizes the fibrinolysis on the fibrin clot. On the fibrin clot, plasmin degrades fibrin into various products, (i.e., D-Dimers). antibodies specific for these products, which do not recognize fibrinogen, have been developed. The presence of these various fibrin degradation products, among which DDimer is the terminal product, is the proof that the fibrinolytic system is in action in response to coagulation activation.