DDimer(DIC) Inpatients Only

Test Code

DDDIC

CPT Codes
85379

Preferred Specimen

Sodium Citrate Plasma

1-blue

Minimum Volume

Blue Tops must be filled to Minimum Fill Indicator Line on tube.

Other Acceptable Specimens

none

Transport Container

BLUE/1

Transport Temperature

Specimen Stability

Whole blood - 4 hours at RT Separated plasma - 8 hours at RT or 1 month frozen

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Sample must be free of clots and hemolysis.

Methodology
Immuno-Turbidimetric

Setup Schedule

Daily on Receipt

Report Available

Upon Completion of Analysis

Reference Range

Ddimer (DIC) = 0.27 - 0.45 ug/mL FEU

Clinical Significance

The specific degradation of fibrin (i.e., fibrinolysis) is the reactive mechanism responding to the formation of fibrin. Plasmin is the fibrinolytic enzyme derived from inactive plasminogen. Plasminogen is converted into plasmin by plasminogen activators. The main plasminogen activators are tissue plasminogen activator (tPA) and pro-urokinase which is activated into urokinase (UK) by, among others, the contact system of coagulation. In the bloodstream, plasmin is rapidly and specifically neutralized by alpha 2-antiplasmin, thereby restricting its fibrinogenolytic activity and localizes the fibrinolysis on the fibrin clot. On the fibrin clot, plasmin degrades fibrin into various products, (i.e., D-Dimers). antibodies specific for these products, which do not recognize fibrinogen, have been developed. The presence of these various fibrin degradation products, among which DDimer is the terminal product, is the proof that the fibrinolytic system is in action in response to coagulation activation.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.