A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Cerebrospinal Fluid Total Protein
Test CodeCPT Codes
84157
Preferred Specimen
Cerebrospinal Fluid
Minimum Volume
Transport Container
CSF collection container or other sterile container
Transport Temperature
Specimen Stability
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Colorimetric
Setup Schedule
Daily upon receipt
Report Available
Limitations
Reference Range
12 - 60 mg/dL
Clinical Significance
Cerebrospinal fluid (CSF) proteins are those that remain in CSF following the ultrafiltration of plasma through the choroidal capillary wall. Some proteins that are unique to CSF are synthesized in the central nervous system. In general, diseases that interrupt the integrity of the capillary endothelial barrier lead to an increase in total CSF protein. CSF protein is generally increased in all types of meningitis, cerebral infarction, brain abscess, meningovascular syphilis, subarachnoid hemorrhage, some brain tumors, trauma to the brain, some cases of multiple sclerosis, encephalomyelitis, and degenerative neurologic diseases. A decreased CSF protein may occur in water intoxication, CSF leak (CSF rhinorrhea or otorrhea), and hyperthyroidism.