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Creatinine/GFR Profile

Test Code
CRNGFR


CPT Codes
82565

Includes
Creatinine and Estimated Glomerular Filtration Rate


Preferred Specimen

Serum (gold top) tube



Minimum Volume
0.5 mL


Other Acceptable Specimens
Lithium Heparin Plasma (green top) tube


Instructions

This test is for Creatinine and Estimated GFR on Plasma or Serum.  For Creatinine measurement on Urine, order URCRN.  For Creatinine Clearance, order 24CC.  For Creatinine measurement on Body Fluids, order MISCRN.



Transport Container

Serum (gold top) tube or Lithium Heparin Plasma (green top) tube



Transport Temperature
Room Temperature or Refrigeration


Specimen Stability
Room Temperature - 5 days; Refrigerated - 30 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Quantity Not Sufficient, EDTA (purple top tube) contamination, IV contamination


Methodology
Colorimetric

Setup Schedule

Daily upon receipt



Report Available
Upon completion of analysis


Limitations
Do not use specimens obtained through catheters used to infuse hyperalimentation fluid. eGFR will be calculated only for patients age 18 years and older.


Reference Range

Creatinine: Birth - 1 Month:        0.6 - 1.2 mg/dL
1 Month - Adult (Female):    0.52 - 1.04 mg/dL
1 Month - Adult (Male):        0.66 - 1.25 mg/dL
eGFR: No range listed



Clinical Significance

Serum creatinine and urinary creatinine excretion is a function of lean body mass in normal persons and shows little or no response to dietary changes. The serum creatinine concentration is higher in men than in women. Since urinary creatinine is excreted mainly by glomerular filtration, with only small amounts due to tubular secretion, serum creatinine and a 24-hour urine creatinine excretion can be used to estimate the glomerular filtration rate. Serum creatinine is increased in acute or chronic renal failure, urinary tract obstruction, reduced renal blood flow, shock, dehydration, and rhabdomyolysis. Causes of low serum creatinine concentration include debilitation and decreased muscle mass. Exercise may cause an increased creatinine clearance. The creatinine clearance rate is unreliable if the urine flow is low.

The National Kidney Disease Education Program (NKDEP), an initiative of the National Institutes of Health, recommends the use of the estimated glomerular filtration rate (eGFR) instead of serum creatinine level alone to assess kidney function for adults older than 18 years.  NKDEP and other organizations encourage laboratories to estimate GFR by using the Modification of Diet in Renal Disease (MDRD) Study equation and routinely report eGFR with all serum creatinine determinations to facilitate earlier diagnosis and treatment of CKD.

This test is for Creatinine and Estimated GFR on Plasma or Serum.  For Creatinine measurement on Urine, order URCRN.  For Creatinine Clearance, order 24CC.  For Creatinine measurement on Body Fluids, order MISCRN.





The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.