A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
24-Hour Creatinine Clearance
Test CodeCPT Codes
82575
Includes
Preferred Specimen
Timed urine specimen
Minimum Volume
Instructions
Collect serum or plasma specimen right before the start of or during urine collection.
Record time of collection and have patient start and stop at the same time on the hour for the number of hours urine is to be collected. Collection is typically for 24 hours, but can also be any number of hours, for example, 4 hours or 12 hours. Record start and stop time or number of hours on collection bottle. If transferring an aliquot to another container, measure volume before transfer and record on transfer container, along with time.
This test is for creatinine clearance. For timed or random creatinine measurement without clearance, order URCRN, which does not require blood draw. For Creatinine measurement on Plasma or Serum with an Estimated Glomerular Filtration Rate, order CRNGFR. For creatinine measurement on body fluids, order MISCRN.
Transport Container
Blood: Serum (gold top) or Lithium Heparin Plasma (green top) tube
Urine: 24-hour urine container or sterile urine cup
Transport Temperature
Specimen Stability
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Colorimetric
Setup Schedule
Monday - Sunday, 8:00 am - 3:00 pm upon receipt
Report Available
Limitations
Reference Range
Total Volume: | 800 - 1800 mL/24 hours |
Serum Creatinine: | |
Birth - 1 month: | 0.6 - 1.2 mg/dL |
1 Month - Adult (Female): | 0.52 - 1.04 mg/dL |
1 Month - Adult (Male): | 0.66 - 1.25 mg/dL |
Creatinine Clearance: | 66 - 166 mL/min |
Clinical Significance
Creatinine Clearance measures the amount of creatinine cleared from the plasma by the kidneys in one minute.
Serum creatinine and urinary creatinine excretion is a function of lean body mass in normal persons and shows little or no response to dietary changes. The serum creatinine concentration is higher in men than in women. Since urinary creatinine is excreted mainly by glomerular filtration, with only small amounts due to tubular secretion, serum creatinine and a 24-hour urine creatinine excretion can be used to estimate the glomerular filtration rate. Serum creatinine is increased in acute or chronic renal failure, urinary tract obstruction, reduced renal blood flow, shock, dehydration, and rhabdomyolysis. Causes of low serum creatinine concentration include debilitation and decreased muscle mass. Exercise may cause an increased creatinine clearance. The creatinine clearance rate is unreliable if the urine flow is low.
This test is for creatinine clearance. For timed or random creatinine measurement without clearance, order URCRN, which does not require blood draw. For Creatinine measurement on Plasma or Serum with an Estimated Glomerular Filtration Rate, order CRNGFR. For creatinine measurement on body fluids, order MISCRN.