A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Vitamin B12
Test CodeCPT Codes
82607
Preferred Specimen
Serum (gold top) tube
Minimum Volume
Other Acceptable Specimens
Transport Container
Serum (gold top) tube or Lithium Heparin Plasma (green top) tube
Transport Temperature
Specimen Stability
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Methodology
Chemiluminescence
Setup Schedule
Daily upon receipt
Report Available
Reference Range
239 - 931 pg/mL
Clinical Significance
Reduced concentrations of vitamin B12 may indicate the presence of vitamin dependent anemia. Elevated concentrations of vitamin B12 have been associated with pregnancy, the use of oral contraceptives and multivitamins and in myeloproliferative diseases, such as chronic granulocytic leukemia and myelomonocytic leukemia. An elevated concentration of vitamin B12 is not known to cause clinical problems. Measurement of vitamin B12 is intended to identify and monitor vitamin B12 deficiency. This can arise from the following: (1) defect in the secretion of Intrinsic Factor, resulting in inadequate absorption from food (pernicious anemia); (2) gastrectomy and malabsorption due to surgical resection; and (3) a variety of bacterial or inflammatory diseases affecting the small intestine.