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Anti-Thrombin III
Test CodeATIII
CPT Codes
85300
Preferred Specimen
1 Blue/ 1Lav
Minimum Volume
Blue top must be filled to Minimum Fill Indicator Line on tube.
Other Acceptable Specimens
none
Instructions
Outreach clients should double-spin the blue top plasma, remove the plasma from the RBC button, and freeze in a polypropylene tube.
Transport Container
Blue top; Polypropylene tube
Transport Temperature
Blue top - ambient; Polypropylene - frozen
Specimen Stability
Blue - 4 hours RT; Plasma - 8 hours RT, 1 month frozen
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Sample must be free of clots and hemolysis.
Methodology
Colorimetric
Setup Schedule
Performed 24/7
Report Available
Upon Completion of Analysis
Reference Range
71 - 122 %
Clinical Significance
Antithrombin III exerts a powerful and immediate inhibitory action on thrombin when heparin is present. Since the first report (1965) of a hereditary deficiency of AT III and its consequences, AT III has been considered an important parameter in spontaneous thromboembolic disorders. The hereditary deficiency, either quantitative or qualitative, is less common than the acquired deficiency. An acquired AT III deficiency has been described in DIC, septic shock, nephrotic syndrome, liver disease and in L-asparaginase treatments.