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Hepatitis C Viral RNA, Genotype, LiPA
Test Code37811
CPT Codes
87902
Preferred Specimen
2 mL plasma collected in a PPT potassium EDTA (white-top) tube or EDTA (lavender-top) tube
Minimum Volume
0.6 mL
Other Acceptable Specimens
Serum
Instructions
Separate serum or plasma from whole blood within 24 hours of collection by centrifugation at 800-1600 x g for 20 minutes at room temperature. Transfer the plasma to a properly identified, sterile, polypropylene screw-cap vial and ship refrigerated or frozen.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 42 days
Refrigerated: 14 days
Frozen: 42 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Unspun PPT tube • Heparinized samples
Methodology
Reverse Transcriptase Polymerase Chain Reaction (RT-PCR)
Setup Schedule
Set up: Daily; Report available: 2-5 days
Reference Range
See Laboratory Report
Clinical Significance
Determination of hepatitis C genotype is often required to select the most appropriate direct acting agent(s) (DAA) for the treatment of hepatitis C. Some DAA's are only effective for the treatment of hepatitis C genotype 1, whereas others may be used for additional genotypes. Refer to the package inserts of the relevant DAA's for guidance. A concurrent patient HCV viral load of >=300 IU/mL is required for this test.