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PD-1, IHC without Interpretation

Test Code
91323


CPT Codes
88342

Preferred Specimen
1 formalin-fixed, paraffin-embedded tissue block


Minimum Volume
1 Block


Other Acceptable Specimens
3 unstained, (+) charged slides, submitted in IHC Specimen Transport Kit


Transport Container
IHC Specimen Transport Kit


Transport Temperature
Room temperature


Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen


Methodology
Immunohistochemistry (IHC)

Setup Schedule
Setup: Mon-Fri a.m.; Report available: Next day


Reference Range
See Laboratory Report


Clinical Significance
The programmed death-1 (PD1) protein is expressed by follicular helper T-cells and is useful in the diagnosis of T-cell lymphomas and in highlighting L&H cells in Hodgkin lymphoma. Anti-PD-1 antibody has been used as anti-tumor immunotherapy agents. This effect is possibly due to the targeting of PD1 expressing tumor-infiltrating lymphocytes which can be enumerated by this antibody.




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.