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ERG, IHC with Interpretation
Test Code91312
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block
Other Acceptable Specimens
Minimum: 3 unstained, positively charged slides submitted in an IHC Specimen transport kit
Instructions
Please include surgical pathology report.
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemistry (IHC)
Setup Schedule
Set up: Mon-Fri a.m.; Report available: 3 days
Reference Range
See Laboratory Report
Clinical Significance
A marker of prostate cancer. Overexpression of ERG protein correlates with TMPRSS2-ERG chromosomal translocation, which are seen in 50-70% of prostate carcinomas. ERG is not expressed in benign prostatic epithelium but can be expressed in PIN. Among other tumor types, ERG is a marker of vascular tumors but is only rarely seen in carcinomas from other tissue sites.
