|
|
| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
FISH, CRLF2-BA Xp22/Yp11
Test Code33681
CPT Codes
88271 (x2), 88275
Includes
If results are not possible from the submitted specimen, the test order will be cancelled and replaced by non-orderable test Cytogenetics Communication.
Preferred Specimen
5 mL whole blood or 3 mL bone marrow collected in a sodium heparin (green-top) or EDTA (lavender-top) tube
Minimum Volume
3 mL whole blood • 1 mL bone marrow
Other Acceptable Specimens
Bone marrow transport tube (available upon request)
Instructions
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Refrigerated: Acceptable
Frozen: Unacceptable
Methodology
Fluorescence in situ Hybridization (FISH)
Setup Schedule
Set up: Daily; Report available: 5-7 days
Reference Range
See Laboratory Report
Clinical Significance
The CRLF2 (cytokine receptor-like factor 2) break apart FISH probe allows for identification of the rearrangement in blood or bone marrow samples. CRLF2 rearrangements are primarily associated with B-cell ALL, commonly fusing with either the immunoglobulin heavy chain gene on chromosome 14, or the P2RY8 gene, located within the pseudoautosomal region (PAR), on chromosomes X and Y.
