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Phosphatidylcholine Antibodies (IgA, IgG, IgM) Panel
Test Code13082
CPT Codes
83520 (x3)<br><strong>This test is not available for New York patient testing.</strong>
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
After collection, allow blood to clot for 30 minutes. Centrifuge at 3,000 rpm for 10 minutes. Separate serum and freeze immediately. Ship frozen.
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Lipemia • Microbially contaminated specimens • More than one freeze-thaw cycle
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)
Setup Schedule
Set up: Varies; Report available: 7 days
Report Available
7 Days
Reference Range
See Laboratory Report
Clinical Significance
The anti-phospholipid syndrome (APS) is a disorder of recurrent vascular thrombosis associated with persistently positive anticardiolipin (aCL) or lupus anticoagulant tests. In patients with APS, anticardiolipin antibodies bind a variety of charged phospholipids, including phosphatidylethanolimine, as well as they do cardiolipin. Lupus patients also have high titers of autoantibodies to various phospholipids, including phosphatidylethanolimine.
Presentations of the syndrome include thrombosis of deep veins of the legs, as well as renal, hepatic, inferior vena cava or sagittal veins. Occlusion of the arterial circulation may be manifested as stroke, ischemic retinopathy, myocardial or bowel infarction, or peripheral gangrene. Thrombosis can occur in veins or arteries of any size. Recurrent pregnancy loss also appears to be the result of thrombosis within the placental vasculature.
Anti-phospholipid antibody tests are supplemental tests and should not be used alone for diagnostic purposes. Diagnosis of anti-phospholipid syndrome must be made in conjunction with other clinical indications.
Presentations of the syndrome include thrombosis of deep veins of the legs, as well as renal, hepatic, inferior vena cava or sagittal veins. Occlusion of the arterial circulation may be manifested as stroke, ischemic retinopathy, myocardial or bowel infarction, or peripheral gangrene. Thrombosis can occur in veins or arteries of any size. Recurrent pregnancy loss also appears to be the result of thrombosis within the placental vasculature.
Anti-phospholipid antibody tests are supplemental tests and should not be used alone for diagnostic purposes. Diagnosis of anti-phospholipid syndrome must be made in conjunction with other clinical indications.
