FISH, MALT Lymph, t(11,18), TC

Test Code

12634

CPT Codes
88271 (x2), 88275<br>Restricted Client Code - Tech Only

Preferred Specimen

5 mL whole blood or 3 mL bone marrow collected in sodium heparin (green-top) tube

Minimum Volume

1 mL whole blood • 1 mL bone marrow

Other Acceptable Specimens

Formalin-fixed, paraffin-embedded tissue block • 5x5mm lymph node tissue or lymph node biopsy collected in a sterile container in Hank's Ringer's solution or culture medium with antibiotics

Instructions

Clinical history and reason for referral are required with test order. Prior therapy and transplant history should be provided with test order.

For bone marrow (1-3 mL) or whole blood (3-5 mL) use sodium heparin (green-top) tube. For lymph node biopsy 5X5 mm in a sterile container in Hank's Ringer's solution or culture medium with antibiotics. Transportation medium available upon request. Formalin-fixed, paraffin-embedded tissue.

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Transport Temperature

Room temperature

Specimen Stability

See Instructions

Methodology
Fluorescence in situ Hybridization

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Sun-Fri; Report available: 5 days

Clinical Significance

The extra-nodal marginal zone B-cell lymphoma (MZBCL) of mucosa associated lymphoid tissue (MALT) type, which comprise 7% of all non-Hodgkin lymphomas, is an indolent disease, involving most often the stomach, where it usually follows chronic gastritis, due to Helicobacter pylori (HP) infection. The t(11;18)(q12;q21) is observed in 20-50% of low-grade MALT lymphoma of the stomach and of the lung, and its presence is often associated with resistance to HP treatment. The API2/MALT1 dual-color, dual-fusion probe is specific for the t(11;18) and its variants.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.