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FISH, Chromosome -5/Deletion 5q31, TC
Test Code12623
CPT Codes
88271 (x2), 88275<br>Restricted Client Code - Tech Only
Preferred Specimen
3 mL bone marrow or 5 mL whole blood collected in sodium heparin (green-top) tube
Minimum Volume
1 mL bone marrow • 3 mL whole blood
Other Acceptable Specimens
Bone marrow or whole blood collected in: sodium heparin (royal blue-top) tube, or sodium heparin, lead-free (tan-top) tube
Instructions
Clinical history and reason for referral are required with test order. Prior therapy and transplant history should be provided with test order.
Submit 1 to 3 mL of bone marrow or 3 to 5 mL whole blood in a sodium heparin (green-top) tube.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Transport Temperature
Room temperature
Specimen Stability
See Instructions
Methodology
Fluorescence in situ Hybridization
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Daily; Report available: 5 days
Clinical Significance
This test is performed in addition to routine hematologic cytogenetic analysis. 100-200 interphase nuclei are examined for the loss of signal(s), consistent with deletion 5q or monosomy 5. These chromosome abnormalities are associated with myeloid disorders, including myelodysplastic syndrome and acute myelogenous leukemia. The test is useful for the evaluation of suboptimal specimens, complex karyotypes, specimens with low mitotic activity, or when a normal karyotype is obtained.