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FISH, NHL, BCL6 3q27 Rearrangement, TC
Test Code12620
CPT Codes
88271 (x2), 88275<br>Restricted Client Code - Tech Only
Preferred Specimen
3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube
Minimum Volume
1 mL bone marrow • 3 mL whole blood
Other Acceptable Specimens
Bone marrow or whole blood collected in: sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube • 5 x5mm fresh tumor tissue collected in culture transport media, or formalin-fixed, paraffin-embedded tissue block
Instructions
Clinical history and reason for referral are required with test order. Prior therapy and transplant history should be provided with test order.
3 mL bone marrow in transport media or sodium heparin (green-top) tube or 5 mL whole blood collected in a sodium heparin (green-top) tube, or 5x5 mm fresh tumor biopsy in transport medium, or formalin-fixed, paraffin-embedded tissue. Ship at room temperature.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Transport Temperature
Room temperature
Specimen Stability
See Instructions
Methodology
Fluorescence In Situ Hybridization
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Daily; Report available: 5 days
Clinical Significance
Chromosomal rearrangements of the BCL6 gene located at 3q27 are found in B-cell non-Hodgkin lymphomas including diffuse large cell lymphoma (DLCL),follicular lymphoma (FL) and marginal zone B-cell lymphoma (MZBCL). DLCL is an aggressive disease that usually responds well to multiagent chemotherapy. Up to 30% of DLCL demonstrate recurrent rearrangements involving the BCL6 gene.
