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Troponin I, High Sensitivity
Test Code34693
CPT Codes
84484
Preferred Specimen
1 mL frozen serum
Minimum Volume
0.5 mL
Other Acceptable Specimens
Frozen plasma collected in a lithium heparin (green-top) tube
Instructions
Collect specimen in SST/red-top or lithium heparin tube. Centrifuge tube and separate serum/plasma into a plastic specimen transport tube. Freeze as soon as possible (within 4 hours).
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: 4 hours
Refrigerated: Unacceptable
Frozen: 40 days
Refrigerated: Unacceptable
Frozen: 40 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Received refrigerated • EDTA plasma • Sodium heparin (green-top) tube
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Daily; Report available: Next day
Limitations
Non-acute coronary syndromes may cause troponin elevation.
Reference Range
≤47 ng/L
Clinical Significance
Troponin I is part of a protein complex which regulates the contraction of striated muscle. In acute coronary syndromes (ACS), it can be detected in blood at 4-8 hours following the onset of chest pain, reaches a peak concentration at 12-16 hours, and remains elevated for 5-9 days. Troponin I has been used as a reliable marker in the diagnosis of perioperative myocardial infarction in patients undergoing cardiac surgery.
