ZAP-70

Test Code

16000

CPT Codes
88184, 88185

Preferred Specimen

5 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

3 mL

Other Acceptable Specimens

Whole blood collected in sodium heparin (green-top) tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 72 hours
Refrigerated: Unacceptable
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • ACD-B (yellow-top) tube

Methodology
Flow Cytometry (FC)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up Daily; Report available: 4 days

Reference Range

ZAP70+/CD19+

<10 %

Clinical Significance

Patients with chronic lymphocytic leukemia have variable outcome. Some live with their disease for more than 25 years and some die within a few years. ZAP70 can predict patients who have aggressive disease and need aggressive therapy.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.