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Theophylline [878X]
Test Code6311
CPT Codes
80198
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.2 mL
Other Acceptable Specimens
Plasma collected in: Sodium heparin (green-top) tube, lithium heparin (green-top) tube, or EDTA (lavender-top) tube
Instructions
Collect as a trough just prior to next dose.
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 6 days
Refrigerated: 7 days
Frozen: 90 days
Refrigerated: 7 days
Frozen: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST)
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon-Thurs p.m.; Report available: Next day
Reference Range
| ≤5 Months | 5.0-10.0 mg/L | |
| >5 Months | 10.0-20.0 mg/L | |
Clinical Significance
Theophylline is used in the treatment of bronchial asthma as well as in the treatment of chronic obstructive pulmonary disease and episodes of prolonged apnea in pre-term infants. Theophylline levels are monitored to assure adequate therapeutic levels are achieved and to avoid toxicity.
