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Tacrolimus and Sirolimus, LC/MS/MS
Test Code70006
CPT Codes
80195, 80197
Includes
[36712] Sirolimus, LC/MS/MS
[70007] Tacrolimus, Highly Sensitive, LC/MS/MS
[70007] Tacrolimus, Highly Sensitive, LC/MS/MS
Preferred Specimen
Please see the individual assays for specimen requirements and stabilities.
Instructions
Collect specimen 1 hour prior to next dose (12 hour trough)
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted blood specimens
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat; Report available: Next day
Reference Range
Tacrolimus
No definitive therapeutic or toxic ranges have been established. Optimal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation.
The following trough range is a suggested guideline: 5.0-20.0 mcg/L
No definitive therapeutic or toxic ranges have been established. Optimal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation.
The following trough range is a suggested guideline: 5.0-20.0 mcg/L
Sirolimus | Trough: 3.0-18.0 mcg/L |
Clinical Significance
Tacrolimus (FK506) and Sirolimus (Rapamycin) are immunosuppressive drugs used in organ transplantation to prevent graft rejection. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.