Pancreastatin, (Plasma)

Test Code

94390

CPT Codes
83519<br>Limited Access Code

Preferred Specimen

10 mL plasma submitted in a plastic transport vial

Patient Preparation
Patient should not be on any medications that may influence Insulin levels, if possible, for at least 48 hours prior to collection.

Minimum Volume

1 mL

Instructions

Collect 10 mL blood directly into ISI's Z-tube™ Preservative and separate as soon as possible. Freeze plasma immediately after separation in plastic transfer vial. Special Z-tube™ Preservatives are available from ISI. Minimum specimen size is 1 mL.

Note: One Z-tube™ may be shared for up to three tests. After centrifuging tube, aliquot 1 mL per test in separate vials, mark with name of test and freeze.

Specimen Note: Specimens for this assay must be collected using the Z-tube. Specimens must be shipped frozen; specimens are not stable at refrigerated or room temperatures. No other specimens are acceptable.

For tumor/tissue and various fluids (i.e. CSF, peritoneal, synovial, etc.) contact the Institute for requirements and special handling.

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 60 days

Methodology
Direct Radioimmunoassay

Setup Schedule

Set up: Daily; Report available: 7 business days (excluding weekends/holidays)

Reference Range

10-135 pg/mL

Clinical Significance

Pancreastatin is a 49 amino acid peptide produced by degradation of Chromo-granin A. It inhibits Chromogranin A and Parathyroid Hormone release. Pancreastatin also inhibits release of Somatostatin upon glucose stimulation. It may also control carbohydrate metabolism and hyperglycemia. Although there are no compounds with significant structural homology with Pancreastatin, there are minor similarities to Gastrin and Anti-Diuretic Hormone. Pancreastatin reduces the the early phase of Glucose induced Insulin release. Suppression of Insulin release upon Glucose stimulation is a characteristic feature of Type II Diabetes. Pancreastatin could play an important therapeutic role in the treatment of diabetes. Pancreastatin also inhibits release of Somatostatin. It may also control carbohydrate metabolism and hyperglycemia.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.