5-Hydroxyindoleacetic acid (5-HIAA)

Test Code

94149

CPT Codes
83497<br>Limited Access Code

Preferred Specimen

10 mL plasma collected in an EDTA (lavender-top) tube

Patient Preparation
Patient should fast overnight prior to collection of specimens

Minimum Volume

0.5 mL

Other Acceptable Specimens

Plasma submitted in an ISI Z-tube™

Instructions

Collect using EDTA "purple top" plasma tube or 10 mL blood directly into ISI's Z-tube™ Preservative, and separate as soon as possible. Freeze plasma immediately after separation. Special Z-tube™ Preservatives are available from ISI. Minimum specimen size is 0.5 mL.

Note: One Z-tube™ may be shared for up to three tests. After centrifuging tube, aliquot 1 mL per test in separate vials, mark with name of test and freeze.

Important Precaution: Specimens for this assay must be collected using EDTA "purple top" or ISI's Z-tube™. Specimens must be shipped frozen; specimens are not stable refrigerated or ambient. No substitute preservatives are acceptable.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 4 months

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature

Methodology
Gas Chromatogragphy/Mass Spectrophotometry (GC-MS/MS)

FDA Status
This test was developed and its performance characteristics have been determined by Inter Science Institute. Values obtained with different methods, laboratories, or kits cannot be used interchangeably with the results on this report. The results cannot be interpreted as absolute evidence of the presence or absence of malignant disease.

Setup Schedule

Set up: Varies; Report available: 4-6 days

Reference Range

Up to 22 ng/mL

Clinical Significance

The ISI plasma 5-HIAA assay correlates well with the 24-hour urinary 5-HIAA assays. This test has been clinically validated for nets patients who previously relied on the 24-hour urinary 5-HIAA. The plasma 5-HIAA saves time, alleviates the need to collect urine in a container for 24 hours and provides equivalent clinical information.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.