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Rheumatoid Arthritis Diagnostic Panel
Test Code17669
CPT Codes
86200, 86431
Includes
Rheumatoid Factor
Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
Preferred Specimen
2 mL serum
Minimum Volume
1 mL
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Plasma
Methodology
Immunoturbidimetry • Immunoassay (IA)
Setup Schedule
Set up: Mon-Fri a.m.; Report available: Next day
Reference Range
Rheumatoid Factor | <14 IU/mL |
CCP Antibody, IgG | |
Negative | <20 |
Weak Positive | 20-39 |
Moderate/Strong Positive | 40-59 |
Strong Positive | >59 |
Clinical Significance
The combination of RF and anti-CCP antibodies provide greater specificity for the diagnosis of Rheumatoid Arthritis (RA). CCP antibodies may be present earlier than RF and often indicate increased erosive disease in RA.