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PTH, Intact and Calcium
Test Code8837
CPT Codes
82310, 83970
Preferred Specimen
PTH, Intact: 1.5 mL plasma collected in a EDTA (lavender-top) tube, and
Calcium: 1 mL serum
Calcium: 1 mL serum
Minimum Volume
1 mL EDTA plasma PTH, Intact • 0.5 mL serum Calcium • 1 mL serum PTH, Intact
Other Acceptable Specimens
PTH, Intact: 2 mL frozen serum
Instructions
Centrifuge and transfer plasma to a transport tube. Label as PLASMA for the PTH, Intact.
Transport Temperature
Frozen
Specimen Stability
EDTA plasma for PTH, Intact
Room temperature: 48 hours
Refrigerated: 72 hours
Frozen: 6 months
Serum for PTH, Intact
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 6 months
Serum for Calcium
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Room temperature: 48 hours
Refrigerated: 72 hours
Frozen: 6 months
Serum for PTH, Intact
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 6 months
Serum for Calcium
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Plasma submitted in sodium heparin (green-top) tube or lithium heparin (green-top) tube
Methodology
PTH: Immunoassay (IA) • Calcium: Spectrophotometry (SP)
Setup Schedule
Set up: Mon-Fri; Report available: 2 days
Reference Range
Calcium
Parathyroid Hormone, Intact
Interpretive Guide
| Age | Male (mg/dL) | Female (mg/dL) |
| <1 Month | 8.4-10.6 | 8.4-10.6 |
| 1-11 Months | 8.7-10.5 | 8.7-10.5 |
| 1-3 Years | 8.5-10.6 | 8.5-10.6 |
| 4-19 Years | 8.9-10.4 | 8.9-10.4 |
| 20-49 Years | 8.6-10.3 | 8.6-10.2 |
| >49 Years | 8.6-10.3 | 8.6-10.4 |
Parathyroid Hormone, Intact
| <1 Year | 7-58 pg/mL | ||||
| 1-7 Years | 12-55 pg/mL | ||||
| 8-18 Years | 12-71 pg/mL | ||||
| ≥19 Years | 14-64 pg/mL | ||||
Interpretive Guide
| Intact PTH | Calcium | |
| Normal Parathyroid | Normal | Normal |
| Hypoparathyroidism | Low or Low Normal | Low |
| Hyperparathyroidism | ||
| Primary | Normal or High | High |
| Secondary | High | Normal or Low |
| Tertiary | High | High |
| Non-Parathyroid | ||
| Hypercalcemia | Low or Low Normal | High |
Clinical Significance
The assay is useful in making the diagnosis of primary hyperparathyroidism, secondary hyperparathyroidism, and a differential diagnosis of hypercalcemia. The assay helps in distinguishing hypercalcemia cause by either primary hyperparathyroidism or malignant disease.
