Protein, Total, 12-Hour Urine with Creatinine

Test Code

16993

CPT Codes
84156, 82570

Preferred Specimen

10 mL aliquot from a well-mixed, unpreserved 12-hour urine collection, submitted in a plastic, leak-proof container

Minimum Volume

2 mL

Other Acceptable Specimens

UA Urinalysis Transport Tube

Instructions

Record 12-hour urine volume on test form and urine vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 5 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Acidified urine

Methodology
Colorimetric (C) • Spectrophotometry (SP)

Setup Schedule

Set up: Sun-Fri; Report available: 1-3 days

Reference Range

Total Volume	200-1700 mL/12 h
Creatinine, 12-Hr Urine
Male	314-1773 mg/12 h
Female	160-1241 mg/12 h
Protein, Total, 12-Hr Urine	8-98 mg/12 h
Protein/Creatinine/12-Hr Urine
Male	20-100 mg/gCre
Female	15-150 mg/gCre
Protein/Creatinine Ratio
Male	0.020-0.100 mg/mgCre
Female	0.015-0.150 mg/mgCre

Clinical Significance

The determination of proteinuria is a well established laboratory procedure for the evaluation of renal disease (glomerular, tubular and overflow proteinuria), urinary tract inflammation, orthostatic proteinuria and preeclampsia (a potential complication of pregnancy). A more rapid clinical assessment of proteinuria using a 12-hour specimen enables a faster diagnosis with subsequent intervention in several of the clinical conditions cited above.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.