PAX8/PPAR[gamma] Translocation, Thyroid Cancer

Test Code

90474

CPT Codes
81401

Preferred Specimen

1 formalin-fixed, paraffin-embedded tissue block

Other Acceptable Specimens

Needle washings (see instructions)

Instructions

Do not reject.
Needle washings in alcohol-based fixative (e.g. CytoLyt®) or formalin-fixed, paraffin-embedded tissue block FNA or FFPE specimens are acceptable for the assay.

All specimens must be accompanied with Pathology report. All FFPE specimens will be examined by a pathologist for confirmation and adequacy. Macrodissection if warranted is performed in the lab.

Transport Temperature

Room temperature

Specimen Stability

FNA or FFPE
Room temperature: 5 years
Refrigerated: 5 years
Frozen: Unacceptable

Needle washings
Room temperature: 30 days
Refrigerated: 30 days
Frozen: Unacceptable

Methodology
Real-Time Polymerase Chain Reaction (PCR)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics Nichols Institute, Chantilly, VA. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Daily; Report available: 5 days

Reference Range

Not detected

Clinical Significance

PAX8/PPARG translocation is associated with 25-50% of follicular thyroid carcinoma but has also been reported at low frequency in follicular adenomas. Correlation with morphologic and clinical findings is thus required.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.