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MUM1, IHC without Interpretation
Test Code16258
CPT Codes
88342-TC
Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block
Other Acceptable Specimens
Minimum: 3 unstained, positively charged slides
Instructions
Please include surgical pathology report.
Transport Container
IHC specimen transport kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen • Specimens other than paraffin block or slides
Methodology
Immunohistochemical Stain
Setup Schedule
Set up: Mon-Fri; Report available: Next day
Reference Range
See Laboratory Report
Clinical Significance
Multiple myeloma oncogene-1 (MUM1) is a 50 kDa protein encoded by the MUM1 gene. IRF4/MUM-1 is expressed in the nuclei and cytoplasm of plasma cells and a small percentage of germinal center (GC) B cells located in the light zone. This assay identifies MUM1 protein in centrocytes and their progeny, plasma cells, activated T cells, and a wide spectrum of hematolymphoid neoplasms derived from these cells. Therefore, this assay can be used as a powerful tool for the identification and the sub classification of lymphoid malignancies.