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MUM1, IHC with Interpretation
Test Code16957
CPT Codes
88342
Preferred Specimen
Formalin-fixed, paraffin embedded tissue block, submitted in an IHC specimen transport kit
Other Acceptable Specimens
3 unstained, positively charged slides
Instructions
Please include surgical pathology report.
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemical Stain
Setup Schedule
Set up: Mon-Fri; Report available: 2 days
Reference Range
See Laboratory Report
Clinical Significance
Multiple myeloma oncogene-1 (MUM1) is a 50 kDa protein encoded by the MUM1 gene. IRF4/MUM1 is expressed in the nuclei and cytoplasm of plasma cells and a small percentage of germinal center (GC) B cells located in the "light zone". This antibody labels MUM1 protein in centrocytes and their progeny, plasma cells, activated T cells, and a wide spectrum of hematolymphoid neoplasms derived from these cells.