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Prolactin, Total and Monomeric
Test Code16122
CPT Codes
84146 (x2)
Includes
Prolactin, Total
Prolactin, Monomeric
Prolactin, Monomeric
Preferred Specimen
1 mL serum
Minimum Volume
0.4 mL
Other Acceptable Specimens
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 6 months
Refrigerated: 7 days
Frozen: 6 months
Methodology
Immunoassay (IA) • PEG Precipitation
Setup Schedule
Set up: Wed; Report available: 3 days
Reference Range
Prolactin, Total
Females (>18 years)
Stages of Puberty (Tanner Stages)
Prolactin, Monomeric
Adult Reference Ranges for Prolactin, Monomeric
Females (>18 years)
| Non-pregnant | 3.0-30.0 ng/mL |
| Pregnant | 10.0-209.0 ng/mL |
| Post-menopausal | 2.0-20.0 ng/mL |
| Males (>18 years) | 2.0-18.0 ng/mL |
Stages of Puberty (Tanner Stages)
| Female Observed | Male Observed | |
| Stage I | 3.6-12.0 ng/mL | ≤10.0 ng/mL |
| Stage II-III | 2.6-18.0 ng/mL | ≤6.1 ng/mL |
| Stage IV-V | 3.2-20.0 ng/mL | 2.8-11.0 ng/mL |
Prolactin, Monomeric
Adult Reference Ranges for Prolactin, Monomeric
| Females | 3.2-25.2 ng/mL |
| Males | 3.4-14.8 ng/mL |
Clinical Significance
For some patients the level of Prolactin measured by immunoassay may be inaccurate with respect to the level of monomeric, biologically active Prolactin. The Macroprolactin by PEG Precipitation test can help to identify if a patient sample has elevated Prolactin due to mostly inactive protein-bound Prolactin (Macroprolactin).
