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Lyme Disease Antibody Index for CNS Infection
Test Code34194
CPT Codes
82040, 82042, 82784 (x2), 86618 (x4)
Preferred Specimen
2 mL serum collected in a serum separator tube (SST) and
2 mL CSF collected in a leak-proof CSF container, within a 24-hour period
2 mL CSF collected in a leak-proof CSF container, within a 24-hour period
Minimum Volume
1 mL serum • 1 mL CSF
Instructions
2 mL serum and 2 mL CSF collected within a 24-hour period
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
CSF and serum collected greater than 24 hours apart
Methodology
Enzyme Linked Immunosorbent Immunoassay (ELISA) • Nephelometry
Setup Schedule
Set up: Tues, Fri; Report available: 1-5 days
Reference Range
Lyme Disease Antibody Index
| ≤1.0 | Negative |
| 1.1-1.2 | Equivocal |
| ≥1.3 | Positive |
| Control Antibody Index | ≤1.0 |
| Albumin Ratio | <0.0078 |
Clinical Significance
The Lyme disease antibody index is used as an aid for diagnosing neuroborreliosis. The assay requires paired serum and CSF. A result set of lyme disease antibody index >1.2, control antibody index <1.0, and albumin ratio <0.0078 provides strong evidence of intrathecal synthesis of b. Burgdorferi antibodies and supports the diagnosis of neuroborreliosis.
