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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Leukocyte Adhesion Deficiency (LAD), Evaluation (CD15s, CD18), Flow Cytometry
Test Code19815
CPT Codes
88184, 88185<br /> **This test is not available for New York patient testing.**
Includes
CD18 (LAD-1), CD15S (LAD-2) Expressions
Preferred Specimen
5 mL whole blood collected in a sodium heparin (green-top) tube
Minimum Volume
2 mL
Instructions
Collect 5 mL of whole blood in a sodium heparin (green-top) tube. Mix thoroughly. Transport at room temperature immediately.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 72 hours
Refrigerated: Unacceptable
Frozen: Unacceptable
Refrigerated: Unacceptable
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Lipemia • Icterus • Clotted specimens • Received refrigerated • Frozen specimens • Coagulants other than sodium heparin
Methodology
Flow Cytometry (FC)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Daily; Report available: 2-4 days
Reference Range
CD18 Expression (LAD-1) | ≥90 %CD18 |
CD15s Expression (LAD-2) | ≥90 %CD15s |
Clinical Significance
LAD is an autosomal recessive immunodeficiency disorder associated with recurrent bacterial and fungal infections. Two forms of LAD have been described. LAD-1 is associated with defective expression of CD18 by neutrophils, whereas LAD-2 is associated with defective expression of CD15s (sialyl-Lewis X).